The term “elastic,” as in “elastic sheet,” is used herein in its ordinary sense and refers to the capacity to resume easily to an original shape after deflection or deformation. 2C, the entirety of the active area 130 may be deflected along with its lower surface 132. Since the nonactive portion of the elastic sheet 120 is immobilized with respect to the substrate 102, the upper surface 134 of the active area 130 may bulge upwardly away from the substrate as well. 4B, the elastic sheet 120 is arranged over the substrate such that the lower surface 122 of the elastic sheet is in contact with the upper substrate surface 102, and terminus 112 of the first channel 108 overlaps terminus 116 of the second channel 114. As a result, a conduit 126 is formed. In another aspect, the invention relates to a method for forming a fluid flow control device, comprising the steps of: (a) providing a substrate having an upper surface; (b) placing an elastic sheet in immobilized relationship to the substrate at a minimum of two immobilization points, thereby positioning an active area of the elastic sheet between the immobilization points over the upper surface of the substrate; and (c) operatively connecting an actuation means to the active area, such that a lower surface of the active area that opposes the upper surface of the substrate may be deflected away from or toward the upper surface of the substrate upon operation of the actuation means.
Dolor Sordo Significado
The active area may then be deflected away from the upper surface of the substrate, thereby forming a fluid-transporting feature between the active area and the upper surface of the substrate. When the actuation means is actuated, the active area is deflected away from the upper surface of the substrate, thereby increasing fluid communication to the fluid-transporting features. In another aspect, the invention relates to a microfluidic device similar to the fluid flow control device as described above, except that the substrate has at least two fluid-transporting microfeatures formed on an upper surface thereof. 3, illustrate another version of the inventive device, wherein the an active area of the elastic sheet, after actuation, is deflected toward a substrate surface to obstruct a fluid-transporting feature formed in part by a channel in lower surface of the elastic sheet. Another suitable silicone material is NuSil CF19-2186 from NuSil Technology of Carpenteria, Calif.
The present elastic sheet may be readily and preferably fabricated from any silicone polymer, since silicone polymers probably have the greatest structural variety, and may have an enormous number of commercially available formulations. Consequently, several techniques have been developed in order to achieve fluid flow control in microfluidic devices. Microfluidic devices do, however, present certain technical challenges that need to be overcome.
Dolor Neuropatico Curso
In any of the above embodiments, suitable materials for forming the substrates are selected based upon physical and chemical characteristics that are desirable for proper functioning of the device. Suitable materials for forming the substrate include, but are not limited to, metals, ceramics, semiconductors, polymers, composites thereof, and laminates thereof. 1, other deflection actions could occur as well, including, but not limited to, wrinkling, arching, or tunneling as discussed below.
Upper surface electrode 142 is located at the upper surface of the active area, and lower surface electrode 144 is located at the lower surface of the active area 130. Although these electrodes are shown as having an identical shape, this is not a requirement. Optionally, the entire active area, after actuation, may be deflected with respect to the substrate.
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1 and 2, illustrate devices wherein substantially the entire elastic sheet, except for the active area, is in an immobilized relationship with respect to the substrate, this is not necessarily the case with all of the inventive devices. Dolor en la zona dorsal de la espalda . 3. The shaded area 129 corresponds to the entire lower surface of the elastic sheet, except for the location of the channel, and represents a locus of immobilization points at which the elastic sheet 120 is immobilized with respect to the substrate 102. A portion of the unshaded area of the elastic sheet represents an active area 130. When in an unactuated state, the lower surface 122 of the elastic sheet 120 is capable of interfacing closely with the upper surface 104 of the substrate 102 to achieve fluid-tight contact therebetween.